Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis

Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis
NCT07332091 | PHASE 2 | INTERVENTIONAL

This is a phase 2, multicenter, randomized, placebo-controlled, double-blind, parallel-group, proof-of-concept study to assess vamifeport in adult participants with homeostatic iron regulator gene-related hereditary hemochromatosis (HFE-HH). The primary objective of the study is to assess the effect of vamifeport treatment on magnetic resonance imaging (MRI)-based liver iron concentration (LIC) in adult participants with HFE-HH.

Trial Information
96 Sites
84 Participants
RECRUITING
18 Years

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SUBMIT
Banner MD Anderson
Gilbert,Arizona,United States,85234
Infinity Clinical Trials
San Diego,California,United States,92108
Medical Oncology Associates of San Diego
San Diego,California,United States,92123
Green Leaf Clinical Trials
Jacksonville,Florida,United States,32258
Indiana University Health University Hospital
Indianapolis,Indiana,United States,46202
Ochsner Medical Complex High Grove
Baton Rouge,Louisiana,United States,70836
Johns Hopkins University School of Medicine
Baltimore,Maryland,United States,21205
American Oncology Partners, PA dba The Center for Cancer and Blood Disorders
Bethesda,Maryland,United States,20817
James M. Stockman Cancer Institute
Frederick,Maryland,United States,21702
University of Michigan Health System (UMHS)
Ann Arbor,Michigan,United States,48109
Aspirus St. Luke's Clinic Duluth Oncology & Hematology
Duluth,Minnesota,United States,55805
Hunterdon Hematology Oncology, LLC
Flemington,New Jersey,United States,08822
Derald H. Ruttenberg Treatment Center
New York,New York,United States,10029
University of North Carolina at Chapel Hill
Chapel Hill,North Carolina,United States,27517
Duke University Medical Center (Duke South Clinics) Duke Medicine Cir
Durham,North Carolina,United States,27710
Hightower Clinical Oklahoma Cancer Center
Oklahoma City,Oklahoma,United States,73174
Intermountain Medical Center
Murray,Utah,United States,84107
Washington State Univ Elson S. Floyd College of Medicine
Spokane,Washington,United States,99202
Royal Brisbane and Women's Hospital
Brisbane,Washington,Australia,99202-2131
Gallipoli Medical Research
Chandler,Washington,Australia,99202-2131
Monash Medical Centre
Clayton,Washington,Australia,99202-2131
Trials West
Perth,Washington,Australia,99202-2131
Westmead Hospital
Westmead,Washington,Australia,99202-2131
Medical University of Innsbruck
Innsbruck,Washington,Austria,99202-2131
Ordensklinikum Linz Barmherzige Schwestern
Linz,Washington,Austria,99202-2131
Medical University Vienna
Vienna,Washington,Austria,99202-2131
Universitair Ziekenhuis Antwerpen (UZA)
Edegem,Washington,Belgium,99202-2131
Ghent University Hospital
Ghent,Washington,Belgium,99202-2131
UZ Brussel
Jette,Washington,Belgium,99202-2131
Centre Hospitalier Universitaire de Lige (CHU de Lige)
Liège,Washington,Belgium,99202-2131
CHU UCL Namur Site Godinne
Yvoir,Washington,Belgium,99202-2131
Libin Cardiovascular Institute University of Calgary
Calgary,Washington,Canada,99202-2131
St. Josephs Healthcare Hamilton
Hamilton,Washington,Canada,99202-2131
University of Manitoba
Winnipeg,Washington,Canada,99202-2131
Fakultn Nemocnice Brno
Brno,Washington,Czechia,99202-2131
Fakultni nemocnice Ostrava
Ostrava,Washington,Czechia,99202-2131
Institut Klinicke a Experimentalni Mediciny
Prague,Washington,Czechia,99202-2131
Aarhus University Hospital
Aarhus,Washington,Denmark,99202-2131
Bispebjerg Hospital
Copenhagen,Washington,Denmark,99202-2131
Copenhagen University Hospital Hvidovre
Hvidovre,Washington,Denmark,99202-2131
Aphp Avicenne
Bobigny,Washington,France,99202-2131
Chu Dupuytren
Limoges,Washington,France,99202-2131
CRMR Maladies du Globule Rouge, Hpital de la Timone
Marseille,Washington,France,99202-2131
CHU de Montpellier Hpital Saint Eloi
Montpellier,Washington,France,99202-2131
GHRMSA
Mulhouse,Washington,France,99202-2131
CHU de Bordeaux Hpital Haut Leveque
Pessac,Washington,France,99202-2131
Centre Hospitalier Lyon SudHospices Civils de Lyon
Pierre-Bénite,Washington,France,99202-2131
Chu Rennes
Rennes,Washington,France,99202-2131
Centre Hospitalier de Saint Brieuc
Saint-Brieuc,Washington,France,99202-2131
CHU Toulouse
Toulouse,Washington,France,99202-2131
Hpital Paul Brousse
Villejuif,Washington,France,99202-2131
Universittsklinikum Freiburg
Freiburg im Breisgau,Washington,Germany,99202-2131
University Hospital Heidelberg
Heidelberg,Washington,Germany,99202-2131
EUGASTRO GmbH
Leipzig,Washington,Germany,99202-2131
MVZ fr Innere Medizin Weinheim
Weinheim,Washington,Germany,99202-2131
Cork University Hospital
Cork,Washington,Ireland,99202-2131
Beaumont Hospital
Dublin,Washington,Ireland,99202-2131
Connolly Hospital Blanchardstown
Dublin,Washington,Ireland,99202-2131
ASL Brindisi Presidio Ospedaliero Di Summa Perrino
Brindisi,Washington,Italy,99202-2131
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan,Washington,Italy,99202-2131
University Hospital of Modena
Modena,Washington,Italy,99202-2131
Fondazione IRCCS San Gerardo dei Tintori
Monza,Washington,Italy,99202-2131
AORN Cardarelli
Naples,Washington,Italy,99202-2131
University of Verona Azienda Ospedaliera Universitaria Integrata Verona
Verona,Washington,Italy,99202-2131
Auckland City Hospital
Auckland,Washington,Netherlands,99202-2131
Maastricht UMC
Maastricht,Washington,Netherlands,99202-2131
Radboud UMC
Nijmegen,Washington,Netherlands,99202-2131
Instytut Hematologii i Transfuzjologii
Warsaw,Washington,Poland,99202-2131
Specjalistyczny Szpital im. Alfreda Sokolowskiego
Wałbrzych,Washington,Poland,99202-2131
Wojewodzki Szpital im. J Gromkowskiego we Wroclawiu
Wroclaw,Washington,Poland,99202-2131
Spitalul Clinic de Urgenta Prof Dr Agrippa IonescuBalotesti
Baloteşti,Washington,Romania,99202-2131
Bistria County Emergency Clinical Hospital
Bistriţa,Washington,Romania,99202-2131
Coltea Clinical Hospital
Bucharest,Washington,Romania,99202-2131
L'Institute Oncologique Prof. Dr. Ion Chiricuta (IOCN)
Cluj-Napoca,Washington,Romania,99202-2131
Prof. Dr.Octavian Fodor Regional Institute of GastroenterologyHepatology
Cluj-Napoca,Washington,Romania,99202-2131
Hospital Universitari Germans Trias i Pujol
Badalona,Washington,Spain,99202-2131
Hospital Clinic Barcelona
Barcelona,Washington,Spain,99202-2131
HUGC Doctor Negrin
LAS Palmas de GC,Washington,Spain,99202-2131
Hospital Universitario La Paz
Madrid,Washington,Spain,99202-2131
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda,Washington,Spain,99202-2131
Althaia Foundation. Hospital Sant Joan de Deu de Manresa
Manresa,Washington,Spain,99202-2131
Hospital Universitario Virgen del Roco
Seville,Washington,Spain,99202-2131
University Hospital Inselspital Bern
Bern,Washington,Switzerland,99202-2131
Centre Hospitalier Universitaire Vaudois
Lausanne,Washington,Switzerland,99202-2131
Epatocentro Ticino
Lugano,Washington,Switzerland,99202-2131
Royal Victoria Hospital
Belfast,Washington,United Kingdom,99202-2131
University Hospitals Bristol and Weston NHS trust, Bristol Haematology and Oncology Centre
Bristol,Washington,United Kingdom,99202-2131
Royal Liverpool University Hospital
Liverpool,Washington,United Kingdom,99202-2131
King's College Hospital
London,Washington,United Kingdom,99202-2131
St Thomas Hospital
London,Washington,United Kingdom,99202-2131
Norfolk and Norwich University Hospital
Norwich,Washington,United Kingdom,99202-2131
Nottingham University Hospitals City Campus
Nottingham,Washington,United Kingdom,99202-2131
John Radcliffe Hospital Oxford University Hospitals NHS
Oxford,Washington,United Kingdom,99202-2131
Derriford Hospital
Plymouth,Washington,United Kingdom,99202-2131
University Hospital Southampton NHS Foundation Trust
Southampton,Washington,United Kingdom,99202-2131
South Warwickshire University Foundation Trust
Warwick,Washington,United Kingdom,99202-2131

Study Eligibility Criteria

Additional Studies

Additional studies can be found at ClinicalTrials.gov