Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis

Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis
NCT07332091 | PHASE 2 | INTERVENTIONAL

This is a phase 2, multicenter, randomized, placebo-controlled, double-blind, parallel-group, proof-of-concept study to assess vamifeport in adult participants with homeostatic iron regulator gene-related hereditary hemochromatosis (HFE-HH). The primary objective of the study is to assess the effect of vamifeport treatment on magnetic resonance imaging (MRI)-based liver iron concentration (LIC) in adult participants with HFE-HH.

Trial Information
96 Sites
84 Participants
RECRUITING
18 Years

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SUBMIT
Banner MD Anderson
Gilbert,Arizona,United States,85234
Infinity Clinical Trials
San Diego,California,United States,92108
Medical Oncology Associates of San Diego
San Diego,California,United States,92123
Green Leaf Clinical Trials
Jacksonville,Florida,United States,32258
Indiana University Health University Hospital
Indianapolis,Indiana,United States,46202
Ochsner Medical Complex High Grove
Baton Rouge,Louisiana,United States,70836
Johns Hopkins University School of Medicine
Baltimore,Maryland,United States,21205
American Oncology Partners, PA dba The Center for Cancer and Blood Disorders
Bethesda,Maryland,United States,20817
James M. Stockman Cancer Institute
Frederick,Maryland,United States,21702
University of Michigan Health System (UMHS)
Ann Arbor,Michigan,United States,48109
Aspirus St. Luke's Clinic Duluth Oncology & Hematology
Duluth,Minnesota,United States,55805
Hunterdon Hematology Oncology, LLC
Flemington,New Jersey,United States,08822
University of North Carolina at Chapel Hill
Chapel Hill,North Carolina,United States,27517
Duke University Medical Center (Duke South Clinics) Duke Medicine Cir
Durham,North Carolina,United States,27710
Hightower Clinical Oklahoma Cancer Center
Oklahoma City,Oklahoma,United States,73174
Intermountain Medical Center
Murray,Utah,United States,84107
Washington State Univ Elson S. Floyd College of Medicine
Spokane,Washington,United States,99202
Royal Brisbane and Women's Hospital
Brisbane,Washington,Australia,99202-2131
Gallipoli Medical Research
Chandler,Washington,Australia,99202-2131
Monash Medical Centre
Clayton,Washington,Australia,99202-2131
Trials West
Perth,Washington,Australia,99202-2131
Westmead Hospital for Medical Research
Westmead,Washington,Australia,2145
Medical University of Innsbruck
Innsbruck,Washington,Austria,2145
Ordensklinikum Linz Barmherzige Schwestern
Linz,Washington,Austria,2145
Medical University Vienna
Vienna,Washington,Austria,2145
Universitair Ziekenhuis Antwerpen (UZA)
Edegem,Washington,Belgium,2145
Ghent University Hospital
Ghent,Washington,Belgium,2145
UZ Brussel
Jette,Washington,Belgium,2145
Centre Hospitalier Universitaire de Lige (CHU de Lige)
Liège,Washington,Belgium,2145
CHU UCL Namur Site Godinne
Yvoir,Washington,Belgium,2145
Libin Cardiovascular Institute University of Calgary
Calgary,Washington,Canada,2145
McMaster UniversitySt. Josephs Healthcare Hamilton
Hamilton,Washington,Canada,2145
University of Manitoba
Winnipeg,Washington,Canada,2145
Fakultn Nemocnice Brno
Brno,Washington,Czechia,2145
Fakultni nemocnice Ostrava
Ostrava,Washington,Czechia,2145
Institut Klinicke a Experimentalni Mediciny
Prague,Washington,Czechia,2145
Aarhus University Hospital
Aarhus,Washington,Denmark,2145
Bispebjerg Hospital
Copenhagen,Washington,Denmark,2145
Copenhagen University Hospital Hvidovre
Hvidovre,Washington,Denmark,2145
Aphp Avicenne
Bobigny,Washington,France,2145
Chu Dupuytren
Limoges,Washington,France,2145
CRMR Maladies du Globule Rouge, Hpital de la Timone
Marseille,Washington,France,2145
CHU de Montpellier Hpital Saint Eloi
Montpellier,Washington,France,2145
GHRMSA
Mulhouse,Washington,France,2145
CHU de Bordeaux Hpital Haut Leveque
Pessac,Washington,France,2145
Centre Hospitalier Lyon SudHospices Civils de Lyon
Pierre-Bénite,Washington,France,2145
Chu Rennes
Rennes,Washington,France,2145
Centre Hospitalier de Saint Brieuc
Saint-Brieuc,Washington,France,2145
CHU Toulouse
Toulouse,Washington,France,2145
Hpital Paul Brousse
Villejuif,Washington,France,2145
Universittsklinikum Freiburg
Freiburg im Breisgau,Washington,Germany,2145
University Hospital Heidelberg
Heidelberg,Washington,Germany,2145
EUGASTRO GmbH
Leipzig,Washington,Germany,2145
MVZ fr Innere Medizin Weinheim
Weinheim,Washington,Germany,2145
Cork University Hospital
Cork,Washington,Ireland,2145
Beaumont Hospital
Dublin,Washington,Ireland,2145
Connolly Hospital Blanchardstown
Dublin,Washington,Ireland,2145
ASL Brindisi Presidio Ospedaliero Di Summa Perrino
Brindisi,Washington,Italy,2145
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan,Washington,Italy,2145
University Hospital of Modena
Modena,Washington,Italy,2145
Fondazione IRCCS San Gerardo dei Tintori
Monza,Washington,Italy,2145
AORN Cardarelli
Naples,Washington,Italy,2145
University of Verona Azienda Ospedaliera Universitaria Integrata Verona
Verona,Washington,Italy,2145
Maastricht UMC
Maastricht,Washington,Netherlands,2145
Radboud UMC
Nijmegen,Washington,Netherlands,2145
Auckland City Hospital
Auckland,Washington,New Zealand,1023
Aotearoa Clinical Trials Trust Middlemore Hospital
Auckland,Washington,New Zealand,2025
Instytut Hematologii i Transfuzjologii
Warsaw,Washington,Poland,2025
Specjalistyczny Szpital im. Alfreda Sokolowskiego
Wałbrzych,Washington,Poland,2025
Wojewodzki Szpital im. J Gromkowskiego we Wroclawiu
Wroclaw,Washington,Poland,2025
Spitalul Clinic de Urgenta Prof Dr Agrippa IonescuBalotesti
Baloteşti,Washington,Romania,2025
Bistria County Emergency Clinical Hospital
Bistriţa,Washington,Romania,2025
Coltea Clinical Hospital
Bucharest,Washington,Romania,2025
L'Institute Oncologique Prof. Dr. Ion Chiricuta (IOCN)
Cluj-Napoca,Washington,Romania,2025
Prof. Dr.Octavian Fodor Regional Institute of GastroenterologyHepatology
Cluj-Napoca,Washington,Romania,2025
Hospital Universitari Germans Trias i Pujol
Badalona,Washington,Spain,2025
Hospital Clinic Barcelona
Barcelona,Washington,Spain,2025
HUGC Doctor Negrin
LAS Palmas de GC,Washington,Spain,2025
Hospital Universitario La Paz
Madrid,Washington,Spain,2025
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda,Washington,Spain,2025
Althaia Foundation. Hospital Sant Joan de Deu de Manresa
Manresa,Washington,Spain,2025
Hospital Universitario Virgen del Roco
Seville,Washington,Spain,2025
University Hospital Inselspital Bern
Bern,Washington,Switzerland,2025
Centre Hospitalier Universitaire Vaudois
Lausanne,Washington,Switzerland,2025
Epatocentro Ticino
Lugano,Washington,Switzerland,2025
Royal Victoria Hospital
Belfast,Washington,United Kingdom,2025
University Hospitals Bristol and Weston NHS trust, Bristol Haematology and Oncology Centre
Bristol,Washington,United Kingdom,2025
Royal Liverpool University Hospital
Liverpool,Washington,United Kingdom,2025
King's College Hospital
London,Washington,United Kingdom,2025
St Thomas Hospital
London,Washington,United Kingdom,2025
Norfolk and Norwich University Hospital
Norwich,Washington,United Kingdom,2025
Nottingham University Hospitals City Campus
Nottingham,Washington,United Kingdom,2025
John Radcliffe Hospital Oxford University Hospitals NHS
Oxford,Washington,United Kingdom,2025
Derriford Hospital
Plymouth,Washington,United Kingdom,2025
University Hospital Southampton NHS Foundation Trust
Southampton,Washington,United Kingdom,2025
South Warwickshire University Foundation Trust
Warwick,Washington,United Kingdom,2025

Study Eligibility Criteria

Additional Studies

Additional studies can be found at ClinicalTrials.gov