- * (a) Estimated age ≥ 15 years. Older minimum age is required in some locations. FOR United Kingdom: Estimated or actual age ≥ 16 years FOR Australia: Estimated or actual age ≥ 18 years AND (b) Estimated or actual weight ≥ 50 kg (110 lbs).
- * Traumatic injury with confirmed or suspected acute major bleeding and/or Revised Assessment of Bleeding and Transfusion (RABT) score ≥ 2
- * Activation of massive transfusion protocol
Traumatic Injury
Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( TAP Study )
NCT05568888 | PHASE 3 | INTERVENTIONAL
This is a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group, large simple trial to investigate the efficacy and safety of a single intravenous (IV) infusion of BE1116 in subjects who have traumatic injury, with confirmed or suspected acute major bleeding and / or predicted to receive a large volume blood product transfusion.
Trial Information
If interested, contact clinicaltrials@cslbehring.com or +1 610-878-4697 for more information
CSL Behring respects your privacy. For an explanation of how CSL Behring will use the information you are submitting, please view our Privacy Policy
UAB Hospital
Birmingham,Alabama,United States,35233
University of South Alabama
Mobile,Alabama,United States,36507
Chandler Regional Medical Center
Chandler,Arizona,United States,85224
Banner University Medical Center Phoenix
Phoenix,Arizona,United States,85006
Valleywise Medical Center
Phoenix,Arizona,United States,85008
St. Joseph's Hospital and Medical Center
Phoenix,Arizona,United States,85013
HonorHealth Scottsdale Osborn Medical Center
Scottsdale,Arizona,United States,85251
University Medical Center Tucson
Tucson,Arizona,United States,85719
UAMS Medical Center
Little Rock,Arkansas,United States,72205
LACUSC Medical Center
Los Angeles,California,United States,90033
Ronald Reagan UCLA Medical Center
Los Angeles,California,United States,90095
Riverside University Health System Medical Center
Moreno Valley,California,United States,92555
UC Irvine
Orange,California,United States,92868
UC Davis Medical Center
Sacramento,California,United States,95817
UC San Diego Medical Center
San Diego,California,United States,92103
San Francisco General Hospital and Trauma Center
San Francisco,California,United States,94110
University of Colorado Aurora
Aurora,Colorado,United States,80045
UC Health Memorial Hospital Central
Colorado Springs,Colorado,United States,80909
Denver Health and Hospital Authority
Denver,Colorado,United States,80204
Medical Center of the Rockies
Loveland,Colorado,United States,80538
Yale New Haven Hospital
New Haven,Connecticut,United States,06510
MedStar Washington Medical Center
Washington,District of Columbia,United States,20010
George Washington University Hospital
Washington,District of Columbia,United States,20037
UF Health Jacksonville
Jacksonville,Florida,United States,32209
University of MiamiRyder Trauma Center
Miami,Florida,United States,33136
Grady Memorial Hospital
Atlanta,Georgia,United States,30303
Augusta University Medical Center
Augusta,Georgia,United States,30912
Northeast Georgia Health System
Gainesville,Georgia,United States,30501
Atrium Health Medical Center of central Georgia
Macon,Georgia,United States,31201
University of Chicago Medical Center
Chicago,Illinois,United States,60637
Indiana University Methodist Hospital
Indianapolis,Indiana,United States,46202
St. Vincent's Hospital
Indianapolis,Indiana,United States,46260
University of Iowa Hospitals and Clinics
Iowa City,Iowa,United States,52242
Kansas University Medical Center
Kansas City,Kansas,United States,66160
University of Kentucky Albert B. Chandler Hospital
Lexington,Kentucky,United States,40536
University of Louisville Hospital
Louisville,Kentucky,United States,40202
University Medical Center of New Orleans
New Orleans,Louisiana,United States,70112
LSU Health Shreveport
Shreveport,Louisiana,United States,71103
Tufts Medical Center
Boston,Massachusetts,United States,02111
University Hospital
Ann Arbor,Michigan,United States,48109
Henry Ford Hospital
Detroit,Michigan,United States,48202
Hennepin County Medical Center
Minneapolis,Minnesota,United States,55415
North Memorial Hospital
Robbinsdale,Minnesota,United States,55422
Health Partners Regions Hospital
Saint Paul,Minnesota,United States,55101
University of Mississippi Medical Center (UMMC)
Jackson,Mississippi,United States,39216
SSM Health St. Louis
Saint Louis,Missouri,United States,63104
Barnes Jewish Hospital
Saint Louis,Missouri,United States,63110
UNMC (University of Nebraska Medical Center)
Omaha,Nebraska,United States,68198
Cooper Health Care
Camden,New Jersey,United States,08103
Rutgers New Jersey Medical School
Newark,New Jersey,United States,07103
Capital Health Regional Medical Center
Trenton,New Jersey,United States,08638
Erie County Medical Center
Buffalo,New York,United States,14215
NYU Langone
Mineola,New York,United States,11501
Jamaica Hospital Medical Center
Richmond Hill,New York,United States,11418
Carolinas Medical Center
Charlotte,North Carolina,United States,28203
Duke University
Durham,North Carolina,United States,27710
Wake Forest Medical Center
Winston-Salem,North Carolina,United States,27157
Sanford Medical Center Fargo
Fargo,North Dakota,United States,58104
Summa Health System Akron Campus
Akron,Ohio,United States,44304
University of Cincinnati Medical Center
Cincinnati,Ohio,United States,45219
MetroHealth Medical Center
Cleveland,Ohio,United States,44109
The Ohio State University
Columbus,Ohio,United States,43210
Mercy Health St. Vincent Medical Center
Toledo,Ohio,United States,43608
University of Oklahoma Health Science Center
Oklahoma City,Oklahoma,United States,73104
Oregon Health and Sciences University Hospital
Portland,Oregon,United States,97239
Penn State Milton S. Hershey Medical Center
Hershey,Pennsylvania,United States,17033
Penn Presbyterian Medical Center
Philadelphia,Pennsylvania,United States,19104
Temple University Hospital
Philadelphia,Pennsylvania,United States,19140
University of Pittsburgh Medical Center Presbyterian
Pittsburgh,Pennsylvania,United States,15213
Reading Hospital
West Reading,Pennsylvania,United States,19611
Brown University (Rhode Island Hospital)
Providence,Rhode Island,United States,02903
Sanford USD Medical Center
Sioux Falls,South Dakota,United States,57117
Erlanger Baroness Hospital
Chattanooga,Tennessee,United States,37403
University of Tennessee Medical Center UTMCK
Knoxville,Tennessee,United States,37920
Regional Medical Center
Memphis,Tennessee,United States,38103
Vanderbilt Hospital and Clinics
Nashville,Tennessee,United States,37027
Dell Seton Medical Center
Austin,Texas,United States,78701
University Medical Center El Paso
El Paso,Texas,United States,79905
Brooke Army Medical Center
Fort Sam Houston,Texas,United States,78234
JPS Health Network (John Peter Smith Hospital)
Fort Worth,Texas,United States,76134
Ben Taub General Hospital Baylor Medical Center Harris Health Network
Houston,Texas,United States,77030
Memorial Hermann Hospital
Houston,Texas,United States,77030
University Hospital
San Antonio,Texas,United States,78229
UT Health Tyler
Tyler,Texas,United States,75701
Intermountain Medical Center
Murray,Utah,United States,84107
University of Utah Hospital
Salt Lake City,Utah,United States,84132
Harborview Medical Center
Seattle,Washington,United States,98104
J.W. Ruby Memorial Hospital
Morgantown,West Virginia,United States,26505
University Hospital
Madison,Wisconsin,United States,53792
Froedtert Memorial Lutheran Hospital
Milwaukee,Wisconsin,United States,53226
Liverpool Hospital
Sydney,Liverpool,Australia,NSW2170
John Hunter Hospital
Sydney,New Lambton,Australia,2305
Royal Prince Alfred Hospital
Sydney,New South Wales,Australia,2305
Royal Adelaide
Adelaide,South Australia,Australia,5000
St. George Hospital
Kogarah,Sydney,Australia,5000
Westmead Hospital
Westmead,Sydney,Australia,2145
Royal Hobart Hospital
Hobart,Tasmania,Australia,7000
Alfred Hospital
Melbourne,Victoria,Australia,3004
Royal Perth Hospital
Perth,Western Australia,Australia,6000
Queen Elizabeth Hospital
Birmingham,Western Australia,United Kingdom,B152GW
Southmead Hospital
Bristol,Western Australia,United Kingdom,BS105NB
Cambridge Addenbrookes University
Cambridge,Western Australia,United Kingdom,CB20QQ
University Hospital Coventry
Coventry,Western Australia,United Kingdom,CV22DX
Hull Royal Infirmary Hull University Teaching Hospitals NHS Trust
Hull,Western Australia,United Kingdom,HU32JZ
Leeds Teaching Hospital
Leeds,Western Australia,United Kingdom,LS13EX
Aintree University Hospital
Liverpool,Western Australia,United Kingdom,L97AL
St. Georges Hospital
London,Western Australia,United Kingdom,SW170QT
Imperial College Healthcare
London,Western Australia,United Kingdom,SW71LY
Royal Victoria Infirmary
Newcastle Upon Tyne,Western Australia,United Kingdom,NE14LP
Queen's Medical Centre, Nottingham University Hospitals NHS Trust
Nottingham,Western Australia,United Kingdom,NG72UH
John Radcliffe Hospital
Oxford,Western Australia,United Kingdom,OX39DU
Sheffield Teaching Hospital
Sheffield,Western Australia,United Kingdom,S102JF
Royal Stoke University Hospital
Stoke-on-Trent,Western Australia,United Kingdom,ST46QG
Study Eligibility Criteria
Additional Studies
Additional studies can be found at ClinicalTrials.gov