- * Male or female at least 18 years of age
- * A diagnosis of ESKD undergoing maintenance dialysis for at least 12 weeks
- * Serum hs-CRP ≥ 2.0 mg/L
- * A diagnosis of diabetes mellitus OR ASCVD
Atherosclerotic Cardiovascular Disease
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis
NCT05485961 | PHASE 2 | INTERVENTIONAL
This is a 2-part (phase 2b/3) prospective, interventional, multicenter, randomized, double blind, placebo controlled study. Part 1 (phase 2b) is a dose-finding study for CSL300 vs placebo. Part 2 (phase 3) aims to assess the efficacy of CSL300 on CV outcomes and safety in subjects with ASCVD or diabetes mellitus and evidence of systemic inflammation who are undergoing maintenance dialysis.
Trial Information
If interested, contact clinicaltrials@cslbehring.com for more information
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Nephrology Consultants, LLC
Huntsville,Alabama,United States,35805
DaVita Clinical Research Montgomery
Montgomery,Alabama,United States,36117
Kidney Disease Medical Group
Glendale,Arizona,United States,91206
AKDHC Medical
Phoenix,Arizona,United States,85018
AKDHC Medical
Tucson,Arizona,United States,85705
National Institute of Clinical Research
Bakersfield,California,United States,93309
National Institute of Clinical Research
Bakersfield,California,United States,93309
Amicis Research Center
Beverly Hills,California,United States,90211
California Institute of Renal Research
Chula Vista,California,United States,91910
National Institute of Clinical Research
Garden Grove,California,United States,92844
Kidney Disease Medical Group
Glendale,California,United States,91206
Renal Consultants Medical Group
Granada Hills,California,United States,91344
California Institute of Renal Research
La Mesa,California,United States,91942
Southern California Medical Research Center
La Palma,California,United States,90623
Academic Medical Research Institute
Los Angeles,California,United States,90022
National Institute of Clinical Research, Inc.
Los Angeles,California,United States,90027
DaVita Carabello Dialysis Center
Los Angeles,California,United States,90033
Renal Medical AssociatesNARI
Lynwood,California,United States,90262
Amicis Research Center
Northridge,California,United States,91324
Van Buren Dialysis Center
Riverside,California,United States,92504
California Institute of Renal Research
San Diego,California,United States,92111
California Institute of Renal Research
San Diego,California,United States,92123
North America Research Institute
San Dimas,California,United States,91773
North America Research Institute
San Dimas,California,United States,91773
Satellite Healthcare
San Jose,California,United States,95126
Amicis Research Center
Vacaville,California,United States,95687
National Institute of Clinical Research, Inc
Victorville,California,United States,92392
DaVita Vista Del Sol Dialysis
Victorville,California,United States,92394
Colorado Kidney Care
Denver,Colorado,United States,80230
Greater Hartford Nephrology, LLC
Bloomfield,Connecticut,United States,06002
Nephrology and Hypertension Associates PC
Middlebury,Connecticut,United States,06762
Horizon Research Group LLC
Coral Gables,Florida,United States,33134
South Florida Nephrology Group, PA
Coral Springs,Florida,United States,33071
Elixia Pines
Hollywood,Florida,United States,33024
South Florida Research Institute
Lauderdale Lakes,Florida,United States,33313
Kidney and Hypertension Specialists of Miami
Miami,Florida,United States,33150
Nephrology Associates of South Miami
Miami,Florida,United States,33173
Elixia Central Florida
Orlando,Florida,United States,32806
Genesis Clinical Research
Tampa,Florida,United States,33603
Florida Premier Research Institute
Winter Park,Florida,United States,32789
Coastal Medical Research, LLC
Brunswick,Georgia,United States,31520
Renal Associates LLC
Columbus,Georgia,United States,31904
Atekha Nephrology Clinic LLC
Statesboro,Georgia,United States,30458
Dunes Clinical Research LLC
Sioux City,Iowa,United States,57049
Kansas Nephrology Physicians, PA
Wichita,Kansas,United States,67214
Michigan Kidney Consultants, PC
Pontiac,Michigan,United States,48341
St. Clair Nephrology Research
Roseville,Michigan,United States,48066
Center for Advanced Kidney Research, PLC
Saint Clair Shores,Michigan,United States,48081
DCR Edina
Minneapolis,Minnesota,United States,55404
DCR Edina
Minneapolis,Minnesota,United States,55404
Southwest Mississippi Nephrology PLLC
Brookhaven,Mississippi,United States,39601
Nephrology and Hypertension Associates Ltd
Tupelo,Mississippi,United States,38801
Clinical Research Consultants
Kansas City,Missouri,United States,64111
GSR Enterprises, Inc.
Lincoln,Nebraska,United States,68510
Great Plains Health Nephrology
North Platte,Nebraska,United States,69101
DaVita Clinical Research Henderson
Henderson,Nevada,United States,89074
Kidney Specialists of Southern Nevada
Las Vegas,Nevada,United States,89106
Seacoast Kidney and Hypertension Specialists
Portsmouth,New Hampshire,United States,03801
DaVita Clinic Research Bronx
Bronx,New York,United States,10461
Mattoo & Bhat Medical Associates, P.C.
College Point,New York,United States,11356
Metrolina Nephrology Associates, PA
Charlotte,North Carolina,United States,28204
Durham Nephrology Associates, PA
Durham,North Carolina,United States,27704
East Carolina University
Greenville,North Carolina,United States,27858
Northeast Clinical Research Center, LLC
Bethlehem,Pennsylvania,United States,18017
Columbia Nephrology
Columbia,South Carolina,United States,29203
DaVita Clinical Research
Spartanburg,South Carolina,United States,29306
Knoxville Kidney Center PLLC
Knoxville,Tennessee,United States,37923
Cussimanio Research Group LLC
Austin,Texas,United States,78751
Research Management, Inc.
Austin,Texas,United States,78758
US Renal Care
Dallas,Texas,United States,75237
Davita Clinical Research
El Paso,Texas,United States,79925
DaVita Clinical Research Horizon
El Paso,Texas,United States,79935
DaVita Clinical Research
Houston,Texas,United States,77054
DaVita Clinical Research
San Antonio,Texas,United States,78229
Davita Clinical Research
San Antonio,Texas,United States,78251
DCRSan Antonio Stone Oak
San Antonio,Texas,United States,78258
DaVita Clinical Research North Houston
Shenandoah,Texas,United States,77384
DCRNorfolk Great Bridge
Chesapeake,Virginia,United States,23320
Peninsula Kidney Associates
Hampton,Virginia,United States,23666
Tidewater Kidney Specialists
Norfolk,Virginia,United States,23502
Concord Repatriation General Hospital
Sydney,New South Wales,Australia,2139
Sunshine Coast University Private Hospital
Nambour,Queensland,Australia,4560
Princess Alexandra Hospital
Woolloongabba,Queensland,Australia,4102
Monash Medical Centre
Clayton,Victoria,Australia,3168
Sunshine Hospital
St Albans,Victoria,Australia,3021
OnzeLieveVrouwziekenhuis VZW
Aalst,Belgium,9300
Imelda Ziekenhuis
Bonheiden,Belgium,2820
AZ SintLucas
Gent,Belgium,9000
Universitair Ziekenhuis Leuven
Leuven,Belgium,3000
CHR de la Citadelle
Liège,Belgium,4000
University of Alberta Hospital
Edmonton,Alberta,Canada,T6G2P4
UKSH Universitatsklinik SchleswigHolstein
Kiel,Germany,24105
Nephrologisches Zentrum VillingenSchwenningen
Villingen-Schwenningen,Germany,78052
Study Eligibility Criteria
Additional Studies
Additional studies can be found at ClinicalTrials.gov