Skip to main content

Heart Failure

Cardiovascular and Renal Treatment in Heart Failure Patients With Hyperkalaemia or at High Risk of Hyperkalaemia
NCT04864795 | Observational

The CARE-HK in HF is a registry study based on the hypothesis that adherence to guidelines is associated with improved real-world outcomes for heart failure (HF) patients. For the purpose of this study, adherence to guidelines is defined as 1) adherence to potassium (sK+) monitoring recommendations, and 2) adherence to renin-angiotensin-aldosterone system inhibitor (RAASi) treatment recommendations, according to the most current local guidelines at the time of assessment. The study aims to evaluate real-world RAASi treatment patterns in clinical practice compared with the guideline-directed medical therapy (GDMT) recommendations. Factors associated with patients achieving GDMT will be evaluated to identify potential barriers.

Trial Information
101 Sites
2000 Participants
18 Years

If interested, contact for more information

CSL Behring respects your privacy. For an explanation of how CSL Behring will use the information you are submitting, please view our Privacy Policy

University of Arkansas for Medical Sciences
Little Rock,Arkansas,United States,72205
UC San Diego Sulpizio Cardiovascular Center
La Jolla,California,United States,92037
Amicis Research Center
Northridge,California,United States,91324
Bridgeport Hospital
Bridgeport,Connecticut,United States,06610
Clearwater Cardiovascular Consultants
Clearwater,Florida,United States,33756
Innovative Research of West Florida, Inc.
Clearwater,Florida,United States,33756
Inpatient Research Clinic, LLC
Hialeah,Florida,United States,33013
Clearwater Cardiovascular Consultants
Largo,Florida,United States,33777
Southwest Florida Research, LLC
Naples,Florida,United States,34102-8143
Peace River Cardiovascular Center
Port Charlotte,Florida,United States,33952
Clearwater Cardiovascular and Interventional Consultants
Safety Harbor,Florida,United States,32695
Cardiology Care Clinics
Eatonton,Georgia,United States,31024
NSC Research
Johns Creek,Georgia,United States,30024
Prairie Cardiovascular Consultants, Ltd.
Springfield,Illinois,United States,62701
Cardiovascular Medicine, P.C.
Davenport,Iowa,United States,52803
Central Cardiology Associates
Elizabethtown,Kentucky,United States,42701
Johns Hopkins University
Baltimore,Maryland,United States,21218
Ascension St. Mary's Hospital
Saginaw,Michigan,United States,48601
Minneapolis Heart Institute Foundation
Minneapolis,Minnesota,United States,55407
Saint Luke's Hospital of Kansas City
Kansas City,Missouri,United States,64111
St. Louis University
Saint Louis,Missouri,United States,63104
Logan Health Research
Kalispell,Montana,United States,59901
Virtua Medical Group PA
Marlton,New Jersey,United States,08053-4197
Raritan Bay Primary and Cardiology Associates
Matawan,New Jersey,United States,07747
Albany Stratton VA Medical Center
Albany,New York,United States,12208
Capital Cardiology Associates
Albany,New York,United States,12211
South Shore University Hospital
Bay Shore,New York,United States,11706
Focus Clinical Research Solutions
Charlotte,North Carolina,United States,28204
Nephrology Associates of Greater Cincinnati
Cincinnati,Ohio,United States,45236
Rama Research LLC
Marion,Ohio,United States,43302
The Heart and Medical Center
Durant,Oklahoma,United States,74701
Capital Area Research, LLC
Camp Hill,Pennsylvania,United States,17011
UPMC Presbyterian Hospital
Pittsburgh,Pennsylvania,United States,15213
UT Southwestern Medical Center
Dallas,Texas,United States,75390
Biopharma Informatic, LLC
Houston,Texas,United States,77084
Texas Cardiology Associates of Houston
Kingwood,Texas,United States,77339
Baylor Scott & White Round Rock
Round Rock,Texas,United States,78665
Baylor Scott & White Health Temple
Temple,Texas,United States,76508
Richmond Cardiology Associates
Mechanicsville,Virginia,United States,23116
William S. Middleton Memorial VA Hospital
Madison,Wisconsin,United States,53705
KH St. Josef Braunau
Braunau Am Inn,Austria,33011
LKH Universitatklinikum Graz
Graz,Austria,NE1 4LP
Ordensklinkum Linz Elisabethinen
Allgemeines Krankenhaus der Stadt Wien
Imed privat
Klinik Floridsdorf
Cliniques Universitaires de Bruxelles Hopital Erasme
Cliniques Universitaires SaintLuc
Grand Hpital de Charleroi
AZ SintBlasius
CHU de Lige
AZ Glorieux
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia
A.O.U. Policlinico di Modena
Centro Cardiologico MonzinoIRCCS
Azienda Ospedaliera Universitaria "Federico II"
Azienda Ospedaliero Universitaria Pisana
Arcispedale S. Maria Nuova Azienda Ospedaliera di Reggio Emilia
Reggio Emilia,Italy
IRCCS San Raffaele Pisana
IRCCS Ospedale Policlinico San Martino
San Martino,Italy
Azienda Servizi Sanitari Triestina
Hospital Universitario Central de Asturias
Hospital Universitario Severo Ochoa
Hospital Universitario Puerta de Hierro Majadahonda
Complejo Hospitalario de Navarra
Hospital Universitari Germans Trias i Pujol
Hospital de la Santa Creu i Sant Pau
Hospital Universitari de Bellvitge
Hospital Universitari Vall d'Hebron
Hospital Universitario Virgen de las Nieves
Juan Ramon Jimenez Hospital
Complejo Hospitalario de Jaen
Complejo Hospitalario Universitario A Corua
La Coruña,Spain
Hospital Universitario de Gran Canaria Dr. Negrin
Las Palmas De Gran Canaria,Spain
Hospital Universitario Infanta Leonor
Hospital Universitario La Paz
Hospital Universitario Ramon y Cajal
Hospital Clinico Universitario Virgen de la Victoria
Hospital Universitario Puerto Real
Puerto Real,Spain
Hospital Universitario Virgen del Roco
Hospital Universitario Virgen Macarena
Kantonsspital Aarau AG
University Hospital Basel
Hpitaux Universitaires de Genve HUG
Centre Hospitalier Universitaire Vaudois
Luzerner Kantonsspital
Kantonsspital St. Gallen
Saint Gallen,Switzerland
Buckinghamshire Healthcare NHS Trust
Amersham,United Kingdom
Bradford Royal Infirmary
Bradford,United Kingdom
Royal Devon and Exeter Hospital (Wonford)
Exeter,United Kingdom
Northwick Park Hospital
Harrow,United Kingdom
Royal Liverpool University Hospital
Liverpool,United Kingdom
Barts Health NHS Trust
London,United Kingdom
King's College Hospital
London,United Kingdom
William Harvey Clinical Research Centre
London,United Kingdom
Royal Victoria Infirmary
Newcastle,United Kingdom
Derriford Hospital
Plymouth,United Kingdom
Whiston Hospital
Rainhill,United Kingdom

Study Eligibility Criteria

  • Patient diagnosed with chronic HF ≥3 months prior to signature of informed consent.
  • Patient has at least 1 record of left ventricular ejection fraction (LVEF) documented in patient medical record in the 24 months prior to signature of informed consent.
  • NOTE: If the proportion of patients with HFpEF exceeds 20% of the target sample size, enrolment of patients with an LVEF ≥50% may be capped.
  • Patient treated with angiotensin-converting enzyme inhibitors (ACEi) / angiotensin receptor blockers (ARB) / angiotensin receptor-neprilysin inhibitors (ARNi) at enrolment.
  • Patient treated with or a candidate for treatment with mineralcorticoid receptor antagonist (MRA) per a relevant treatment guideline at enrolment.
  • Patient at increased risk of hyperkalaemia due to one or more of the following:
  • Current hyperkalaemia (sK+ >5.0 mEq/L) at enrolment
  • Record of documented hyperkalaemia (sK+ >5.0 mEq/l) in the 24 months prior to signature of informed consent
  • estimated glomerular filtration rate (eGFR) <45 mL/min/1.73m2, or Chronic Kidney Disease (CKD) stage ≥3b.
  • Patient judged by the Investigator to have sufficient cognitive ability to participate
  • Signed informed consent provided.
  • Patient on renal replacement therapy or mechanical circulatory support.
  • Disease other than HF with expected survival <1 year.
  • Patient is participating in, or being screened for, an interventional trial, with the exception of interventional trials relating to SARS-CoV-2.
  • Patient already found to be intolerant to MRA for reasons other than hyperkalaemia or renal impairment.

Additional Studies

Additional studies can be found at