Heart Failure

Cardiovascular and Renal Treatment in Heart Failure Patients With Hyperkalaemia or at High Risk of Hyperkalaemia
NCT04864795 | Observational

The CARE-HK in HF is a registry study based on the hypothesis that adherence to guidelines is associated with improved real-world outcomes for heart failure (HF) patients. For the purpose of this study, adherence to guidelines is defined as adherence to RAASi treatment recommendations, according to the AHA/ACC and ESC guidelines. Objectives relating to patiromer effectiveness will only be evaluated if a sufficient number of patients are available. The study aims to evaluate in patients at high risk of hyperkalaemia; patients treated with ACEi/ARB/ARNi, and either treated with or candidates for treatment with MRA.

Trial Information
104 Sites
2000 Participants
Recruiting
18 Years

If interested, contact clinicaltrials@cslbehring.com for more information

CSL Behring respects your privacy. For an explanation of how CSL Behring will use the information you are submitting, please view our Privacy Policy

SUBMIT
University of Arkansas for Medical Sciences
Little Rock,Arkansas,United States,72205
UC San Diego Sulpizio Cardiovascular Center
La Jolla,California,United States,92037
Amicis Research Center
Northridge,California,United States,91324
Bridgeport Hospital
Bridgeport,Connecticut,United States,06610
Clearwater Cardiovascular Consultants
Clearwater,Florida,United States,33756
Innovative Research of West Florida, Inc.
Clearwater,Florida,United States,33756
Inpatient Research Clinic, LLC
Hialeah,Florida,United States,33013
Clearwater Cardiovascular Consultants
Largo,Florida,United States,33777
Southwest Florida Research, LLC
Naples,Florida,United States,34102-8143
Peace River Cardiovascular Center
Port Charlotte,Florida,United States,33952
Clearwater Cardiovascular and Interventional Consultants
Safety Harbor,Florida,United States,32695
Cardiology Care Clinics
Eatonton,Georgia,United States,31024
NSC Research
Johns Creek,Georgia,United States,30024
Prairie Cardiovascular Consultants, Ltd.
Springfield,Illinois,United States,62701
Cardiovascular Medicine, P.C.
Davenport,Iowa,United States,52803
Central Cardiology Associates
Elizabethtown,Kentucky,United States,42701
Johns Hopkins University
Baltimore,Maryland,United States,21218
Ascension St. Mary's Hospital
Saginaw,Michigan,United States,48601
Minneapolis Heart Institute Foundation
Minneapolis,Minnesota,United States,55407
Saint Luke's Hospital of Kansas City
Kansas City,Missouri,United States,64111
St. Louis University
Saint Louis,Missouri,United States,63104
Logan Health Research
Kalispell,Montana,United States,59901
Virtua Medical Group PA
Marlton,New Jersey,United States,08053-4197
Raritan Bay Primary and Cardiology Associates
Matawan,New Jersey,United States,07747
Albany Stratton VA Medical Center
Albany,New York,United States,12208
Capital Cardiology Associates
Albany,New York,United States,12211
South Shore University Hospital
Bay Shore,New York,United States,11706
Focus Clinical Research Solutions
Charlotte,North Carolina,United States,28204
Nephrology Associates of Greater Cincinnati
Cincinnati,Ohio,United States,45236
Rama Research LLC
Marion,Ohio,United States,43302
The Heart and Medical Center
Durant,Oklahoma,United States,74701
Capital Area Research, LLC
Camp Hill,Pennsylvania,United States,17011
UPMC Presbyterian Hospital
Pittsburgh,Pennsylvania,United States,15213
UT Southwestern Medical Center
Dallas,Texas,United States,75390
Biopharma Informatic, LLC
Houston,Texas,United States,77084
Texas Cardiology Associates of Houston
Kingwood,Texas,United States,77339
Baylor Scott & White Round Rock
Round Rock,Texas,United States,78665
Baylor Scott & White Health Temple
Temple,Texas,United States,76508
Richmond Cardiology Associates
Mechanicsville,Virginia,United States,23116
William S. Middleton Memorial VA Hospital
Madison,Wisconsin,United States,53705
KH St. Josef Braunau
Braunau Am Inn,Austria,33011
LKH Universitatklinikum Graz
Graz,Austria,NE1 4LP
Ordensklinkum Linz Elisabethinen
Linz,Austria
Allgemeines Krankenhaus der Stadt Wien
Wien,Austria
Imed privat
Wien,Austria
Klinik Floridsdorf
Wien,Austria
Cliniques Universitaires de Bruxelles Hopital Erasme
Brussels,Belgium
Cliniques Universitaires SaintLuc
Bruxelles,Belgium
Grand Hpital de Charleroi
Charleroi,Belgium
AZ SintBlasius
Dendermonde,Belgium
CHU de Lige
Liège,Belgium
AZ Glorieux
Ronse,Belgium
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
Bologna,Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
Brescia,Italy
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
Ferrara,Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia
Foggia,Italy
A.O.U. Policlinico di Modena
Modena,Italy
Centro Cardiologico MonzinoIRCCS
Monza,Italy
Azienda Ospedaliera Universitaria "Federico II"
Napoli,Italy
Azienda Ospedaliero Universitaria Pisana
Pisa,Italy
Arcispedale S. Maria Nuova Azienda Ospedaliera di Reggio Emilia
Reggio Emilia,Italy
IRCCS San Raffaele Pisana
Roma,Italy
IRCCS Ospedale Policlinico San Martino
San Martino,Italy
Azienda Servizi Sanitari Triestina
Triest,Italy
Hospital Universitario Central de Asturias
Oviedo,Spain
Hospital Universitario Severo Ochoa
Leganés,Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda,Spain
Complejo Hospitalario de Navarra
Pamplona,Spain
Hospital Universitari Germans Trias i Pujol
Badalona,Spain
Hospital clinic de Barcelona
Barcelona,Spain
Hospital de la Santa Creu i Sant Pau
Barcelona,Spain
Hospital Universitari de Bellvitge
Barcelona,Spain
Hospital Universitari Vall d'Hebron
Barcelona,Spain
Hospital Universitario Virgen de las Nieves
Granada,Spain
Juan Ramon Jimenez Hospital
Huelva,Spain
Complejo Hospitalario de Jaen
Jaén,Spain
Complejo Hospitalario Universitario A Corua
La Coruña,Spain
Hospital Universitario de Gran Canaria Dr. Negrin
Las Palmas De Gran Canaria,Spain
Hospital Universitario Clinico San Carlos
Madrid,Spain
Hospital Universitario Infanta Leonor
Madrid,Spain
Hospital Universitario La Paz
Madrid,Spain
Hospital Universitario Ramon y Cajal
Madrid,Spain
Hospital Clinico Universitario Virgen de la Victoria
Málaga,Spain
Hospital Universitario Puerto Real
Puerto Real,Spain
Hospital Universitario Virgen del Roco
Sevilla,Spain
Hospital Universitario Virgen Macarena
Sevilla,Spain
Hosp. Universitari Sant Joan de Reus
Tarragona,Spain
Kantonsspital Aarau AG
Aarau,Switzerland
University Hospital Basel
Basel,Switzerland
Hpitaux Universitaires de Genve HUG
Geneva,Switzerland
Centre Hospitalier Universitaire Vaudois
Lausanne,Switzerland
Luzerner Kantonsspital
Luzern,Switzerland
Kantonsspital St. Gallen
Saint Gallen,Switzerland
Buckinghamshire Healthcare NHS Trust
Amersham,United Kingdom
Bradford Royal Infirmary
Bradford,United Kingdom
Royal Devon and Exeter Hospital (Wonford)
Exeter,United Kingdom
Northwick Park Hospital
Harrow,United Kingdom
Royal Liverpool University Hospital
Liverpool,United Kingdom
Barts Health NHS Trust
London,United Kingdom
King's College Hospital
London,United Kingdom
William Harvey Clinical Research Centre
London,United Kingdom
Royal Victoria Infirmary
Newcastle,United Kingdom
Derriford Hospital
Plymouth,United Kingdom
Whiston Hospital
Rainhill,United Kingdom

Study Eligibility Criteria

  • Adult aged ≥18 years at enrolment.
  • Patient diagnosed with chronic HF ≥3 months prior to signature of informed consent.
  • Patient has at least 1 record of LVEF documented in patient medical record in the 24 months prior to signature of informed consent. NOTE: If the proportion of patients with HFpEF exceeds 20% of the target sample size, enrolment of patients with an LVEF ≥50% may be capped.
  • Patient treated with ACEi/ARB/ARNi at enrolment.
  • Patient treated with or a candidate for treatment with MRA per a relevant treatment guideline (e.g., HF, CKD, resistant hypertension) at enrolment.
  • Patient at increased risk of hyperkalaemia due to one or more of the following:
  • Current hyperkalaemia (sK+ >5.0 mEq/l) at enrolment
  • Record of documented hyperkalaemia (sK+ >5.0 mEq/l) in the 24 months prior to signature of informed consent
  • eGFR <45 ml/min/1.73 m2, or CKD Stage ≥3b.
  • Patient judged by the Investigator to have sufficient cognitive ability to participate.
  • Signed informed consent provided
  • Patient on renal replacement therapy or mechanical circulatory support.
  • Disease other than HF with expected survival <1 year.
  • Patient is participating in, or being screened for, an interventional trial, with the exception of interventional trials relating to SARS-CoV-2.
  • Patient already found to be intolerant to MRA for reasons other than hyperkalaemia or renal impairment.

Additional Studies

Additional studies can be found at ClinicalTrials.gov