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Acute Coronary Syndrome

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome
NCT03473223 | Phase 3 | Interventional

This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI), including those managed with percutaneous coronary intervention (PCI) or medically managed.

Trial Information
161 Sites
18200 Participants
Recruiting
18 Years

If interested, contact clinicaltrials@cslbehring.com for more information

Advanced Cardiovascular LLC
Alexander City, Alabama, 35010, United States
Cardiology, PC
Birmingham, Alabama, 35211, United States
Heart Center Research, LLC
Huntsville, Alabama, 35801, United States
University of South Alabama College of Medicine
Mobile, Alabama, 36617, United States
Mercy Gilbert Medical Center
Gilbert, Arizona, 85297, United States
Mayo Clinic Arizona
Phoenix, Arizona, 85054, United States
Southern Arizona V.A. Healthcare System
Tucson, Arizona, 85723, United States
NEA Baptist Clinic
Jonesboro, Arkansas, 72401, United States
Central Arkansas Veterans Healthcare System
Little Rock, Arkansas, 72205, United States
Central Cardiology Medical Center
Bakersfield, California, 93308, United States
John Muir Health and Cardiovascular Institute
Concord, California, 94520, United States
Valley Clinical Trials
Covina, California, 91723, United States
Orange Coast Memorial Hospital
Fountain Valley, California, 92708, United States
Sharp Grossmont Hospital
La Mesa, California, 91942, United States
South Orange County Surgical Medical Group
Laguna Hills, California, 92653, United States
Long Beach Memorial Medical Center
Long Beach, California, 90806, United States
Cardiovascular Innovation and Research Center
Long Beach, California, 90813, United States
Los Alamitos Cardiovascular
Los Alamitos, California, 90720, United States
University of California Los Angeles
Los Angeles, California, 90038, United States
V.A. Greater Los Angeles Healthcare System
Los Angeles, California, 90073, United States
Saint Jude Heritage Healthcare
Mission Viejo, California, 92691, United States
Hoag Memorial Hospital Presbyterian
Newport Beach, California, 92663, United States
Valley Clinical Trials, Inc.
Northridge, California, 91325, United States
Valley Clinical Trials
Pasadena, California, 91105, United States
San Diego Cardiac Center
San Diego, California, 92123, United States
V.A. San Diego Health Care System
San Diego, California, 92161, United States
Ventura Clinical Trials
Ventura, California, 93003, United States
John Muir Medical Center Walnu
Walnut Creek, California, 94598, United States
Interventional Cardiology Medical Group
West Hills, California, 91307, United States
Aurora Denver Cardiology Associates
Aurora, Colorado, 80012, United States
CardioVascular Institute of North Colorado Cardiology Clinic
Greeley, Colorado, 80631, United States
Danbury Hospital
Danbury, Connecticut, 06810, United States
Christiana Hospital
Newark, Delaware, 19718, United States
MedStar Clinical Research Center
Washington, District of Columbia, 20010, United States
George Washington University Medical Center
Washington, District of Columbia, 20037, United States
Clearwater Cardiovascular and Interventional Consultants
Clearwater, Florida, 33756, United States
Cardiology Research Associates
Daytona Beach, Florida, 32117, United States
Jim Moran Heart and Vascular Center
Fort Lauderdale, Florida, 33308, United States
Integrative Research Associates Inc.
Fort Lauderdale, Florida, 33312, United States
University of Florida
Gainesville, Florida, 32610, United States
Shands Jacksonville Medical Center
Jacksonville, Florida, 32209, United States
Cardiology Partners Research Institute
Palm Beach Gardens, Florida, 33410, United States
Cardiology Consultants
Pensacola, Florida, 32501, United States
Clearwater Cardiovascular and Interventional Consultants
Safety Harbor, Florida, 34695, United States
Intercoastal Medical Group
Sarasota, Florida, 34239, United States
Pepin Heart Institute
Tampa, Florida, 33613, United States
Piedmont Heart Institute
Athens, Georgia, 30606, United States
Emory University
Atlanta, Georgia, 30322-1059, United States
Augusta University
Augusta, Georgia, 30912, United States
IACT Health
Columbus, Georgia, 31904, United States
Atlanta V.A. Medical Center
Decatur, Georgia, 30033, United States
Northeast Georgia Medical Center
Gainesville, Georgia, 30501, United States
Memorial Health University Medical Center
Savannah, Georgia, 31404, United States
Saint Luke's Boise Medical Center
Boise, Idaho, 83712, United States
Jesse Brown V.A. Medical Center
Chicago, Illinois, 60612, United States
Advanced Heart Care Group
Fairview Heights, Illinois, 62208, United States
Advocate Lutheran General Hospital
Park Ridge, Illinois, 60068, United States
OSF MultiSpecialty Group
Peoria, Illinois, 61614, United States
Midwest Cardiovascular Research
Elkhart, Indiana, 46514, United States
Indiana Heart Physicians, Inc.
Indianapolis, Indiana, 46237, United States
Indiana Heart Hospital
Indianapolis, Indiana, 46250, United States
The Saint Vincent Heart Center of Indiana
Indianapolis, Indiana, 46290, United States
IU Health Ball Memorial Hospital Physicians, Inc
Muncie, Indiana, 47303, United States
Reid Health
Richmond, Indiana, 47374, United States
Northeast Iowa Medical Education Foundation
Waterloo, Iowa, 50702, United States
Norton Cardiovascular Associates
Louisville, Kentucky, 40205, United States
Cambridge Medical Trials
Alexandria, Louisiana, 71301, United States
Cardiovascular Associates Research
Covington, Louisiana, 70433, United States
Cardiovascular Institute of the South
Houma, Louisiana, 70361-4176, United States
Cardiovascular Institute of the South
Lafayette, Louisiana, 70503, United States
Tulane University Health Science Center
New Orleans, Louisiana, 70112, United States
Ochsner Clinic Foundation
New Orleans, Louisiana, 70121, United States
Overton Brooks V.A. Medical Center
Shreveport, Louisiana, 71101, United States
Eastern Maine Medical Center
Bangor, Maine, 04401, United States
Maine Medical Center Bramhall Campus
Portland, Maine, 04102, United States
Washington Adventist Hospital
Takoma Park, Maryland, 20912, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
Healthy Heart Cardiology
Grandville, Michigan, 49418, United States
Western Michigan University Homer Striker MD School of Medicine
Kalamazoo, Michigan, 49048, United States
Mid Michigan Regional Medical Center
Midland, Michigan, 48670, United States
Saint Joseph Mercy Oakland
Pontiac, Michigan, 48341, United States
Ascension Providence Rochester Hospital
Rochester, Michigan, 48307, United States
Covenant Medical Center
Saginaw, Michigan, 48602, United States
Ascension MacombOakland Hospital Warren Campus
Warren, Michigan, 48236, United States
Michigan Heart and Vascular Institute
Ypsilanti, Michigan, 48197, United States
Saint Lukes Hospital
Duluth, Minnesota, 55805, United States
Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, 55401, United States
Regions Hospital
Saint Paul, Minnesota, 55101, United States
Jackson Heart Clinic
Jackson, Mississippi, 39216, United States
Cardiology Associates of North Mississippi
Tupelo, Mississippi, 38801, United States
University of Missouri Health System
Columbia, Missouri, 65212, United States
North Kansas City Hospital
North Kansas City, Missouri, 64116, United States
Washington University
Saint Louis, Missouri, 63110, United States
Glacier View Cardiology
Kalispell, Montana, 59901, United States
Nebraska Heart Institute
Lincoln, Nebraska, 68526, United States
University Medical Center
Las Vegas, Nevada, 89102, United States
Advanced Heart Care LLC
Bridgewater, New Jersey, 08807, United States
Cooper University Hospital
Camden, New Jersey, 08103, United States
Our Lady of Lourdes Medical Center
Camden, New Jersey, 08103, United States
Jersey Shore University Medical Center Meridian Health
Neptune, New Jersey, 07753, United States
Saint Michael's Medical Center
Newark, New Jersey, 07102, United States
AtlantiCare Regional Medical Center
Pomona, New Jersey, 08240, United States
Cardiovascular Associates of the Delaware Valley
Vineland, New Jersey, 08360, United States
VMG Cardiology, Westwood
Westwood, New Jersey, 07675, United States
Montefiore Medical Center Albert Einstein College of Medicine
Bronx, New York, 10461, United States
Jacobi Medical Center
Bronx, New York, 10461, United States
Buffalo Heart Group
Buffalo, New York, 14215, United States
Saint Joseph's Hospital Cardiac Catheterization Associates
Liverpool, New York, 13088, United States
Mount Sinai Medical Center
New York, New York, 10029, United States
Lenox Hill Hospital
New York, New York, 10075, United States
Westchester Medical Center
Valhalla, New York, 10595, United States
UNC Hospitals Heart and Vascular Center at Meadowmont
Chapel Hill, North Carolina, 27517, United States
Duke University Hospital
Durham, North Carolina, 27710, United States
Moses H. Cone Memorial Hospital
Greensboro, North Carolina, 27401-1020, United States
High Point Regional Hospital
High Point, North Carolina, 27262, United States
Southeastern Cardiology & Cardiovascular Clinic
Lumberton, North Carolina, 28358, United States
Wake Forest University Health Sciences, Dept. of Cardiovascular Medicine
Winston-Salem, North Carolina, 27157, United States
Trinity Medical Group
Minot, North Dakota, 58701, United States
Summa Health
Akron, Ohio, 44304, United States
Aultman Hospital
Canton, Ohio, 44710, United States
University of Cincinnati
Cincinnati, Ohio, 45219, United States
Cincinnati V.A. Medical Center
Cincinnati, Ohio, 45220, United States
MetroHealth System
Cleveland, Ohio, 44109, United States
Miami Valley Hospital
Dayton, Ohio, 45409, United States
North Ohio Research Ltd.
Elyria, Ohio, 44035, United States
North Ohio Heart Center
Sandusky, Ohio, 44870, United States
Mercy Saint Vincent Medical Center
Toledo, Ohio, 43608, United States
University of Toledo Medical Center
Toledo, Ohio, 43614, United States
Genesis Health Care System
Zanesville, Ohio, 43701, United States
South Oklahoma Heart Research
Oklahoma City, Oklahoma, 73135, United States
Oklahoma Heart Institute
Tulsa, Oklahoma, 74104, United States
Holy Spirit Cardiology
Camp Hill, Pennsylvania, 17001, United States
Chambersburg Hospital
Chambersburg, Pennsylvania, 17201, United States
Milton Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104, United States
V.A. Pittsburgh Healthcare System
Pittsburgh, Pennsylvania, 15240, United States
Advanced Cardiology Specialists
Scranton, Pennsylvania, 18508, United States
AnMed Health Medical Center
Anderson, South Carolina, 29621, United States
Greenville Hospital System
Greenville, South Carolina, 29605, United States
Upstate Cardiology, PA
Greenville, South Carolina, 29607, United States
Advanced Cardiology Associates
Greenwood, South Carolina, 29646, United States
Black Hills Cardiovascular Research
Rapid City, South Dakota, 57701, United States
The Chattanooga Heart Institute
Chattanooga, Tennessee, 37404, United States
Tennova Health Care Turkey Creek Medical Center
Knoxville, Tennessee, 37934, United States
V.A. Medical Center Memphis
Memphis, Tennessee, 38104, United States
Baptist Clinical Research Institute
Memphis, Tennessee, 38120, United States
Parkway Cardiology Associates, PC
Oak Ridge, Tennessee, 37830, United States
Cardiovascular Research of Knoxville
Powell, Tennessee, 37849, United States
PharmaTex Research
Amarillo, Texas, 79016, United States
Amarillo Heart Clinical Research Institute
Amarillo, Texas, 79106, United States
V.A. North Texas Health Care System
Dallas, Texas, 75216, United States
Revival Research Institute
McKinney, Texas, 75069, United States
Mission Research Institute, LLC
New Braunfels, Texas, 78130, United States
Revival Research Institute, LLC
Sherman, Texas, 75092, United States
Hillcrest Family Health Center
Waco, Texas, 76710-4023, United States
Wichita Falls Heart Clinic
Wichita Falls, Texas, 76301, United States
Inova Fairfax Hospital
Falls Church, Virginia, 22042-3300, United States
McGuire Research Institute
Richmond, Virginia, 23249, United States
Winchester Cardiology and Vascular Medicine
Winchester, Virginia, 22601, United States
Providence Everett Medical Center
Everett, Washington, 98201, United States
The Heart and Vascular Center Holy Family Memorial
Manitowoc, Wisconsin, 54220, United States

Study Eligibility Criteria

  • Male or female least 18 years of age
  • Evidence of myocardial necrosis, consistent with type I (spontaneous) MI
  • No suspicion of acute kidney injury
  • Evidence of multivessel coronary artery disease
  • Presence of established cardiovascular risk factor(s):
  • Diabetes mellitus on pharmacotherapy OR
  • 2 or more of the following: age ≥ 65 years, prior history of MI, peripheral arterial disease
  • Ongoing hemodynamic instability
  • Evidence of hepatobiliary disease
  • Evidence of severe chronic kidney disease
  • Plan to undergo scheduled coronary artery bypass graft surgery as treatment for the index MI
  • Known history of allergies, hypersensitivity, or deficiencies to soy bean, peanut or albumin

Additional Studies

Additional studies can be found at ClinicalTrials.gov